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Showing 1 to 12 of 2012 entries
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Radioopaque contrast media. 18. Derivatives of 2-(3-amino-2,4,6-triiodophenyl)alkanoic acids.

Journal of medicinal chemistry

Felder E, Pitrè D, Fumagalli L, Lorenzotti E.
PMID: 5441146
J Med Chem. 1970 May;13(3):559-61. doi: 10.1021/jm00297a057.

No abstract available.

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Felder E, Pitrè D, Fumagalli L, et al. Radioopaque contrast media. 18. Derivatives of 2-(3-amino-2,4,6-triiodophenyl)alkanoic acids. J Med Chem. 1970;13(3):559-61doi: 10.1021/jm00297a057.
Felder, E., Pitrè, D., Fumagalli, L., & Lorenzotti, E. (1970). Radioopaque contrast media. 18. Derivatives of 2-(3-amino-2,4,6-triiodophenyl)alkanoic acids. Journal of medicinal chemistry, 13(3), 559-61. https://doi.org/10.1021/jm00297a057
Felder, E, et al. "Radioopaque contrast media. 18. Derivatives of 2-(3-amino-2,4,6-triiodophenyl)alkanoic acids." Journal of medicinal chemistry vol. 13,3 (1970): 559-61. doi: https://doi.org/10.1021/jm00297a057
Felder E, Pitrè D, Fumagalli L, Lorenzotti E. Radioopaque contrast media. 18. Derivatives of 2-(3-amino-2,4,6-triiodophenyl)alkanoic acids. J Med Chem. 1970 May;13(3):559-61. doi: 10.1021/jm00297a057. PMID: 5441146.
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Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26.

Journal of medicinal chemistry

Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y, Kristensson L, Kakol-Palm D, Tyrchan C, Wellner E, Bauer U, Brodin P, Svensson Henriksson A.
PMID: 25875054
J Med Chem. 2015 May 14;58(9):4086. doi: 10.1021/acs.jmedchem.5b00479. Epub 2015 Apr 15.

No abstract available.

Cite
Georgsson J, Bergström F, Nordqvist A, et al. Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26. J Med Chem. 2015;58(9):4086doi: 10.1021/acs.jmedchem.5b00479.
Georgsson, J., Bergström, F., Nordqvist, A., Watson, M. J., Blundell, C. D., Johansson, M. J., Petersson, A. U., Yuan, Z. Q., Zhou, Y., Kristensson, L., Kakol-Palm, D., Tyrchan, C., Wellner, E., Bauer, U., Brodin, P., & Svensson Henriksson, A. (2015). Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26. Journal of medicinal chemistry, 58(9), 4086. https://doi.org/10.1021/acs.jmedchem.5b00479
Georgsson, Jennie, et al. "Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26." Journal of medicinal chemistry vol. 58,9 (2015): 4086. doi: https://doi.org/10.1021/acs.jmedchem.5b00479
Georgsson J, Bergström F, Nordqvist A, Watson MJ, Blundell CD, Johansson MJ, Petersson AU, Yuan ZQ, Zhou Y, Kristensson L, Kakol-Palm D, Tyrchan C, Wellner E, Bauer U, Brodin P, Svensson Henriksson A. Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26. J Med Chem. 2015 May 14;58(9):4086. doi: 10.1021/acs.jmedchem.5b00479. Epub 2015 Apr 15. PMID: 25875054.
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Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester.

International journal of medicinal chemistry

Hébert MJ, Flewelling AJ, Clark TN, Levesque NA, Jean-François J, Surette ME, Gray CA, Vogels CM, Touaibia M, Westcott SA.
PMID: 25834744
Int J Med Chem. 2015;2015:418362. doi: 10.1155/2015/418362. Epub 2015 Mar 05.

Two novel boron compounds containing caffeic acid phenethyl ester (CAPE) derivatives have been prepared and characterized fully. These new compounds and CAPE have been investigated for potential antioxidant and antimicrobial properties and their ability to inhibit 5-lipoxygenase and whether...

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Hébert MJ, Flewelling AJ, Clark TN, et al. Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester. Int J Med Chem. 2015;2015:418362doi: 10.1155/2015/418362.
Hébert, M. J., Flewelling, A. J., Clark, T. N., Levesque, N. A., Jean-François, J., Surette, M. E., Gray, C. A., Vogels, C. M., Touaibia, M., & Westcott, S. A. (2015). Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester. International journal of medicinal chemistry, 2015418362. https://doi.org/10.1155/2015/418362
Hébert, Martin J G, et al. "Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester." International journal of medicinal chemistry vol. 2015 (2015): 418362. doi: https://doi.org/10.1155/2015/418362
Hébert MJ, Flewelling AJ, Clark TN, Levesque NA, Jean-François J, Surette ME, Gray CA, Vogels CM, Touaibia M, Westcott SA. Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester. Int J Med Chem. 2015;2015:418362. doi: 10.1155/2015/418362. Epub 2015 Mar 05. PMID: 25834744; PMCID: PMC4365380.
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No Denying It: Medicinal Chemistry Training Is in Big Trouble.

Journal of medicinal chemistry

Rafferty MF.
PMID: 27668824
J Med Chem. 2016 Dec 22;59(24):10859-10864. doi: 10.1021/acs.jmedchem.6b00741. Epub 2016 Oct 07.

There has been little consensus between the pharmaceutical industry and academic communities concerning the best approach to train medicinal chemists for drug discovery. For decades the pharmaceutical industry has shown preference for synthetic organic graduates over candidates with degrees...

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Rafferty MF. No Denying It: Medicinal Chemistry Training Is in Big Trouble. J Med Chem. 2016;59(24):10859-10864doi: 10.1021/acs.jmedchem.6b00741.
Rafferty, M. F. (2016). No Denying It: Medicinal Chemistry Training Is in Big Trouble. Journal of medicinal chemistry, 59(24), 10859-10864. https://doi.org/10.1021/acs.jmedchem.6b00741
Rafferty, Michael F. "No Denying It: Medicinal Chemistry Training Is in Big Trouble." Journal of medicinal chemistry vol. 59,24 (2016): 10859-10864. doi: https://doi.org/10.1021/acs.jmedchem.6b00741
Rafferty MF. No Denying It: Medicinal Chemistry Training Is in Big Trouble. J Med Chem. 2016 Dec 22;59(24):10859-10864. doi: 10.1021/acs.jmedchem.6b00741. Epub 2016 Oct 07. PMID: 27668824.
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Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.

Journal of medicinal chemistry

Degorce SL, Bailey A, Callis R, De Savi C, Ducray R, Lamont G, MacFaul P, Maudet M, Martin S, Morgentin R, Norman RA, Peru A, Pink JH, Plé PA, Roberts B, Scott JS.
PMID: 27003331
J Med Chem. 2016 Apr 14;59(7):3576. doi: 10.1021/acs.jmedchem.6b00364. Epub 2016 Mar 22.

No abstract available.

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Degorce SL, Bailey A, Callis R, et al. Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. J Med Chem. 2016;59(7):3576doi: 10.1021/acs.jmedchem.6b00364.
Degorce, S. L., Bailey, A., Callis, R., De Savi, C., Ducray, R., Lamont, G., MacFaul, P., Maudet, M., Martin, S., Morgentin, R., Norman, R. A., Peru, A., Pink, J. H., Plé, P. A., Roberts, B., & Scott, J. S. (2016). Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. Journal of medicinal chemistry, 59(7), 3576. https://doi.org/10.1021/acs.jmedchem.6b00364
Degorce, Sébastien L, et al. "Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators." Journal of medicinal chemistry vol. 59,7 (2016): 3576. doi: https://doi.org/10.1021/acs.jmedchem.6b00364
Degorce SL, Bailey A, Callis R, De Savi C, Ducray R, Lamont G, MacFaul P, Maudet M, Martin S, Morgentin R, Norman RA, Peru A, Pink JH, Plé PA, Roberts B, Scott JS. Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. J Med Chem. 2016 Apr 14;59(7):3576. doi: 10.1021/acs.jmedchem.6b00364. Epub 2016 Mar 22. PMID: 27003331.
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Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives.

Journal of medicinal chemistry

Zheng K, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y.
PMID: 27673700
J Med Chem. 2016 Oct 13;59(19):9276. doi: 10.1021/acs.jmedchem.6b01369. Epub 2016 Sep 27.

No abstract available.

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Zheng K, Iqbal S, Hernandez P, et al. Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives. J Med Chem. 2016;59(19):9276doi: 10.1021/acs.jmedchem.6b01369.
Zheng, K., Iqbal, S., Hernandez, P., Park, H., LoGrasso, P. V., & Feng, Y. (2016). Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives. Journal of medicinal chemistry, 59(19), 9276. https://doi.org/10.1021/acs.jmedchem.6b01369
Zheng, Ke, et al. "Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives." Journal of medicinal chemistry vol. 59,19 (2016): 9276. doi: https://doi.org/10.1021/acs.jmedchem.6b01369
Zheng K, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y. Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives. J Med Chem. 2016 Oct 13;59(19):9276. doi: 10.1021/acs.jmedchem.6b01369. Epub 2016 Sep 27. PMID: 27673700; PMCID: PMC5066129.
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Design and Synthesis of Novel Hybrid Molecules against Malaria.

International journal of medicinal chemistry

Lödige M, Hiersch L.
PMID: 25734014
Int J Med Chem. 2015;2015:458319. doi: 10.1155/2015/458319. Epub 2015 Feb 05.

The effective treatment of malaria can be very complex: Plasmodium parasites develop in multiple stages within a complex life cycle between mosquitoes as vectors and vertebrates as hosts. For the full and effective elimination of parasites, an effective drug...

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Lödige M, Hiersch L. Design and Synthesis of Novel Hybrid Molecules against Malaria. Int J Med Chem. 2015;2015:458319doi: 10.1155/2015/458319.
Lödige, M., & Hiersch, L. (2015). Design and Synthesis of Novel Hybrid Molecules against Malaria. International journal of medicinal chemistry, 2015458319. https://doi.org/10.1155/2015/458319
Lödige, Melanie, and Hiersch, Luisa. "Design and Synthesis of Novel Hybrid Molecules against Malaria." International journal of medicinal chemistry vol. 2015 (2015): 458319. doi: https://doi.org/10.1155/2015/458319
Lödige M, Hiersch L. Design and Synthesis of Novel Hybrid Molecules against Malaria. Int J Med Chem. 2015;2015:458319. doi: 10.1155/2015/458319. Epub 2015 Feb 05. PMID: 25734014; PMCID: PMC4334980.
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Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

Journal of medicinal chemistry

Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC.
PMID: 25738634
J Med Chem. 2015 Mar 26;58(6):2862. doi: 10.1021/acs.jmedchem.5b00199. Epub 2015 Mar 04.

No abstract available.

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Zimmerman SS, Khatri A, Garnier-Amblard EC, et al. Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators". J Med Chem. 2015;58(6):2862doi: 10.1021/acs.jmedchem.5b00199.
Zimmerman, S. S., Khatri, A., Garnier-Amblard, E. C., Mullasseril, P., Kurtkaya, N. L., Gyoneva, S., Hansen, K. B., Traynelis, S. F., & Liotta, D. C. (2015). Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators". Journal of medicinal chemistry, 58(6), 2862. https://doi.org/10.1021/acs.jmedchem.5b00199
Zimmerman, Sommer S, et al. "Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators"." Journal of medicinal chemistry vol. 58,6 (2015): 2862. doi: https://doi.org/10.1021/acs.jmedchem.5b00199
Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC. Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators". J Med Chem. 2015 Mar 26;58(6):2862. doi: 10.1021/acs.jmedchem.5b00199. Epub 2015 Mar 04. PMID: 25738634; PMCID: PMC4415028.
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Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.

Journal of medicinal chemistry

Moreno-Viguri E, Jiménez-Montes C, Martín-Escolano R, Santivañez-Veliz M, Martin-Montes A, Azqueta A, Jimenez-Lopez M, Zamora Ledesma S, Cirauqui N, López de Ceráin A, Marín C, Sánchez-Moreno M, Pérez-Silanes S.
PMID: 28257207
J Med Chem. 2017 Mar 23;60(6):2604. doi: 10.1021/acs.jmedchem.7b00263. Epub 2017 Mar 03.

No abstract available.

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Moreno-Viguri E, Jiménez-Montes C, Martín-Escolano R, et al. Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives. J Med Chem. 2017;60(6):2604doi: 10.1021/acs.jmedchem.7b00263.
Moreno-Viguri, E., Jiménez-Montes, C., Martín-Escolano, R., Santivañez-Veliz, M., Martin-Montes, A., Azqueta, A., Jimenez-Lopez, M., Zamora Ledesma, S., Cirauqui, N., López de Ceráin, A., Marín, C., Sánchez-Moreno, M., & Pérez-Silanes, S. (2017). Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives. Journal of medicinal chemistry, 60(6), 2604. https://doi.org/10.1021/acs.jmedchem.7b00263
Moreno-Viguri, Elsa, et al. "Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives." Journal of medicinal chemistry vol. 60,6 (2017): 2604. doi: https://doi.org/10.1021/acs.jmedchem.7b00263
Moreno-Viguri E, Jiménez-Montes C, Martín-Escolano R, Santivañez-Veliz M, Martin-Montes A, Azqueta A, Jimenez-Lopez M, Zamora Ledesma S, Cirauqui N, López de Ceráin A, Marín C, Sánchez-Moreno M, Pérez-Silanes S. Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives. J Med Chem. 2017 Mar 23;60(6):2604. doi: 10.1021/acs.jmedchem.7b00263. Epub 2017 Mar 03. PMID: 28257207.
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Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.

Journal of medicinal chemistry

Siegrist R, Pozzi D, Jacob G, Torrisi C, Colas K, Braibant B, Mawet J, Pfeifer T, de Kanter R, Roch C, Kessler M, Moon R, Corminboeuf O, Bezençon O.
PMID: 28234473
J Med Chem. 2017 Mar 09;60(5):2163. doi: 10.1021/acs.jmedchem.7b00219. Epub 2017 Feb 24.

No abstract available.

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Siegrist R, Pozzi D, Jacob G, et al. Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. J Med Chem. 2017;60(5):2163doi: 10.1021/acs.jmedchem.7b00219.
Siegrist, R., Pozzi, D., Jacob, G., Torrisi, C., Colas, K., Braibant, B., Mawet, J., Pfeifer, T., de Kanter, R., Roch, C., Kessler, M., Moon, R., Corminboeuf, O., & Bezençon, O. (2017). Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. Journal of medicinal chemistry, 60(5), 2163. https://doi.org/10.1021/acs.jmedchem.7b00219
Siegrist, Romain, et al. "Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers." Journal of medicinal chemistry vol. 60,5 (2017): 2163. doi: https://doi.org/10.1021/acs.jmedchem.7b00219
Siegrist R, Pozzi D, Jacob G, Torrisi C, Colas K, Braibant B, Mawet J, Pfeifer T, de Kanter R, Roch C, Kessler M, Moon R, Corminboeuf O, Bezençon O. Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. J Med Chem. 2017 Mar 09;60(5):2163. doi: 10.1021/acs.jmedchem.7b00219. Epub 2017 Feb 24. PMID: 28234473.
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Molecular dynamics: new advances in drug discovery.

European journal of medicinal chemistry

Milardi D, Pappalardo M.
PMID: 25466447
Eur J Med Chem. 2015 Feb 16;91:1-3. doi: 10.1016/j.ejmech.2014.10.078. Epub 2014 Nov 01.

No abstract available.

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Milardi D, Pappalardo M. Molecular dynamics: new advances in drug discovery. Eur J Med Chem. 2014;91:1-3doi: 10.1016/j.ejmech.2014.10.078.
Milardi, D., & Pappalardo, M. (2015). Molecular dynamics: new advances in drug discovery. European journal of medicinal chemistry, 911-3. https://doi.org/10.1016/j.ejmech.2014.10.078
Milardi, Danilo, and Pappalardo, Matteo. "Molecular dynamics: new advances in drug discovery." European journal of medicinal chemistry vol. 91 (2015): 1-3. doi: https://doi.org/10.1016/j.ejmech.2014.10.078
Milardi D, Pappalardo M. Molecular dynamics: new advances in drug discovery. Eur J Med Chem. 2015 Feb 16;91:1-3. doi: 10.1016/j.ejmech.2014.10.078. Epub 2014 Nov 01. PMID: 25466447.
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Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents.

International journal of medicinal chemistry

Sharma MC, Sharma S.
PMID: 25574393
Int J Med Chem. 2014;2014:739646. doi: 10.1155/2014/739646. Epub 2014 Dec 10.

A QSAR study on thiophenyl derivatives as SGLT2 inhibitors as potential antidiabetic agents was performed with thirty-three compounds. Comparison of the obtained results indicated the superiority of the genetic algorithm over the simulated annealing and stepwise forward-backward variable method...

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Sharma MC, Sharma S. Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents. Int J Med Chem. 2014;2014:739646doi: 10.1155/2014/739646.
Sharma, M. C., & Sharma, S. (2014). Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents. International journal of medicinal chemistry, 2014739646. https://doi.org/10.1155/2014/739646
Sharma, Mukesh C, and Sharma, Smita. "Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents." International journal of medicinal chemistry vol. 2014 (2014): 739646. doi: https://doi.org/10.1155/2014/739646
Sharma MC, Sharma S. Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents. Int J Med Chem. 2014;2014:739646. doi: 10.1155/2014/739646. Epub 2014 Dec 10. PMID: 25574393; PMCID: PMC4276301.
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Showing 1 to 12 of 2012 entries